Comparison of the efficacy of oral or intra-articular application of corticosteroids in the treatment of frozen shoulder: an experimental study in rats
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Acta Orthop Traumatol Turkish. 2022 Jan;56(1):64-70. doi: 10.5152/j.aott.2021.20332.
OBJECTIVE: The aim of this study was to compare the clinical and histopathological effects of oral versus intra-articular corticosteroid application in a rat model of frozen shoulder.
Methods: In this study, eighty adult Sprague-Dawley rats were used. The animals were divided into 5 equal groups. The frozen shoulder model was created by immobilizing the animals’ shoulders with internal fixation with sutures for 8 weeks. At week 8, the sham (n: 16) and control (n: 16) groups were sacrificed to collect data on healthy and affected shoulders. Additionally, at week 8, 50 mg/kg methylprednisolone was started for the oral treatment group, and a single dose of 0.5 mg/kg triamcinolone acetonide was injected for the intraoral treatment group. articular. The effect of additional steroid treatment was expected for 2 weeks, then all remaining treatment and natural course groups were sacrificed at week 10.
RESULTS: After sacrifice, specimens collected as “en bloc” scapulothoracic disarticulation were randomly divided into two groups for range of motion measurement and histopathological examination. The shoulder range of motion of the control group (frozen shoulder model) in all directions was less than that of the sham (healthy) group (P 0.05). Histopathologically, no statistically significant difference was observed between the groups for the signs of frozen shoulder which were found in the immobilized group (P > 0.05). Histopathologically, immobilization has been shown to cause thickening of the capsule that cannot be resolved by treatment. (P
CONCLUSION: In frozen shoulder disease, intra-articular injection of steroids appears to be superior in increasing range of motion than treatment with oral steroids.
PMID:35234132 | DOI:10.5152/j.autt.2021.20332